Description
Vyvanse
Lisdexamfetamine, sold under the brand name Vyvanse among others, is a stimulant medication that is mainly used to treat attention deficit hyperactivity disorder (ADHD) in people over the age of five as well as moderate-to-severe binge eating disorder in adults.[11] Lisdexamfetamine is taken by mouth. Its effects generally begin within 2 hours and last for up to 14 hours.[11][12] In the United Kingdom, it is usually less preferred than methylphenidate for the treatment of children.[13]
Common side effects of lisdexamfetamine include loss of appetite, anxiety, diarrhea, trouble sleeping, irritability, and nausea.[11] Rare but serious side effects include mania, sudden cardiac death in those with underlying heart problems, and psychosis.[11] It has a high potential for substance abuse per the DEA.[11][12] Serotonin syndrome may occur if used with certain other medications.[11] Its use during pregnancy may result in harm to the baby and use during breastfeeding is not recommended by the manufacturer.[14][11][12]
Lisdexamfetamine is an inactive prodrug that works after being converted by the body into dextroamphetamine, a central nervous system (CNS) stimulant.[11][15] Chemically, lisdexamfetamine is composed of the amino acid L-lysine, attached to dextroamphetamine.[16]
Lisdexamfetamine was approved for medical use in the United States in 2007.[11] In 2019, it was the 79th most commonly prescribed medication in the United States, with more than 9 million prescriptions.[17][18] It is a Class B controlled substance in the United Kingdom and a Schedule II controlled substance in the United States
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